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| Effects of Bushen Huoxue decoction on immunological condition in patients with lupus nephritis of liver-kidney Yin deficiency syndrome |
| Hits 1723 Download times 2263 Received:July 18, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2015.06.03 |
| Key Words
Bushen Huoxue decoction;lupus nephritis;liver-kidney Yin deficiency;immunology |
| Author Name | Affiliation | | YUE Ying | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Police Hospital, Tianjin 300042, China | | JI Yan-wen | Tianjin Medical University General Hospital, Tianjin 300052, China | | ZHANG Mian-zhi | Tianjin Police Hospital, Tianjin 300042, China | | LIU Wei | Nephrology Department, Tianjin Police Hospital, Tianjin 300042, China | | CHEN Jing | Tianjin Police Hospital, Tianjin 300042, China |
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| Abstract
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| [Objective] To observe the clinical curative efects of Bushen Huoxue decoction on immunological condition in patients with lupus nephritis(LN)of Liver-kidney Yin deficiency. [Methods] Thirty-six LN patients were randomly divided into foundation treatment group(n=18) and combined treatment group(n=18); steroids and cyclophosphamide(CTX) were administered to all patients,while Bushen Huoxue decoction were only administered to patients in the mixed treatment group.After 3-month treatment,SLE disease activity index score(SLEDAI Score),C3, C4, 24 h urine protein quantity,endogenous creatinine clearance rate(Ccr), blood urea nitrogen(BUN), T lymphocytes subsets(CD3+、CD4+、CD8+), daily dosage of steroids and ill-effects were detected in both groups.[Results] Compared with foundation treatment group, combined treatment group could significantly decrease SLEDAI score,24 h urine protein,urea nitrogen, daily dosage of steroids and ill-effects and down-regulate the level of CD8+ T cell(P<0.05). [Conclusion] Bushen Huoxue decoction can significantly ameliorate LN of liver-kidney Yin deficiency syndrome and reduce the dosage of steroids by correcting immune dysfunction. |
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