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| Studies on dendrobium compound control GLP-1 in aged diabetes mellitus rat |
| Hits 1646 Download times 1428 Received:July 05, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2015.06.08 |
| Key Words
Dendrobium compound;GLP-1;diabetes mellitus |
| Author Name | Affiliation | E-mail | | LIU Yun | Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China | | | SHI Hong | Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China | shihong3327@sina.com.cn | | LIN Xin-jun | Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China | | | ZHENG Xiao-ling | Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China | | | XU Qian | Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China | |
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| Abstract
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| [Objective] Observed the influence of Dendrobium compound(DC) affected on GLP-1 expression on aged diabetes. [Methods] Female Wistar rats were divided into normal control group, model group, DC Mixture low dose group, DC Mixture high dose group, metformin control group. Detect 0.5 and 2.5 h GLP-1 of each group. Immunohistochemistry was used to evaluate the protein expression of GLP-1.[Results] The difference between 0.5 and 2.5 h of GLP-1 in the DC low group were lower than the molding group(P<0.05); the difference between 0.5 and 2.5 h of GLP-1 in the DC high group were higher markedly than the molding group(P <0.01);GLP-1 was not found in the small intestine.[Conclusion] The DC low group may slow down the metabolism of GLP-1, and the DC high group may promote the secretion of GLP-1 in 0.5 h. |
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