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| Research of prescription screening of echinacoside solid lipid nanoparticles |
| Hits 1685 Download times 1276 Received:June 29, 2015 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2015.06.10 |
| Key Words
echinacoside;solid lipid nanoparticles;excipients;physical and chemical properties |
| Author Name | Affiliation | E-mail | | CHEN Jing | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | TONG Ling | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Zhi-dong | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lonerliuzd@163.com | | LI Chun-hua | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | DING Ling-ling | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GUO Li-li | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] Explore the impact of different excipients for physical and chemical properties of echinacoside solid lipid nanoparticles(SLN), and thus made little tips for the study of water-soluble drugs prescription monomer SLN. [Methods] Fumble Myrj52, Compritol 888 ATO, glyceryl monostearate, soy lecithin and other accessories affecting the physicochemical properties of echinacoside SLN using a single variable method.[Results] With increasing of Myrj52 amount, the nanoparticles particle size decreased, zeta potential increased, encapsulation rate increased; with increasing of amounts of Compritol 888 ATO, encapsulation efficiency decreased slightly, zeta potential decreases; with increasing of amounts of glycerol monostearate, particle size increased significantly, encapsulation efficiency decreased slightly, zeta potential decreased; with increasing amounts of lecithin, particles size increased significantly, significantly reduced the potential entrapment rate.[Conclusion] Various accessories alone has a greater impact on physicochemical properties of echinacoside SLN, this study provides inspiration for prescription screening of water-soluble drug SLN. |
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