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| Effects of shengqing Jiangzhuo prescription to improve the insulin sensitivity of MSG rats |
| Hits 1516 Download times 1978 Received:October 17, 2015 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2016.01.08 |
| Key Words
Shengqing Jiangzhuo prescription;MSG rats;insulin resistance |
| Author Name | Affiliation | E-mail | | DU Juan | TCM Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG De-qin | TCM Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | deqin123@163com | | WEN Jing | TCM Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HUANG Chun-li | TCM Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Qing-xia | TCM Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHOU Wen-long | TCM Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Hua | TCM Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To study the mechanisms and effects of Shengqing Jiangzhuo prescription to improve the insulin sensitivity of MSG rats. [Methods] Copy the MSG obese rat models, which were randomly divided into model group, rosiglitazone group, fenofibrate group, three dose of Shengqing Jiangzhuo prescription. Then choose 8 normal rats as the normal control group. Measure the levels of glucose in skeletal muscle and the level of leptin in serum after administration for 50 days. Real-time PCR detect the expression level of PPAR, leptin, IRS1, IRS2, GLUT4 in skeletal muscle. [Results] Compared with the normal group, the model group improved the level of glucose in skeletal muscle and the level of leptin in serum significantly (P<0.01), and decreased the expression of PPAR, leptin, IRS1, IRS2, GLUT4 significantly (P<0.01, P<0.05). Compared with the model group, each of groups had some improvements of the level of glucose in skeletal muscle and the level of leptin and the level of genes expression. [Conclusion] Shengqing Jiangzhuo prescription improve the insulin sensitivity in MSG rats which by activating the genes expression of PPAR and leptin. |
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