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| Effects of EGB761 on PON-1 and ox-LDL in rabbits with atherosclerosis |
| Hits 1675 Download times 2094 Received:November 28, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2016.02.07 |
| Key Words
EGB761;PON-1;ox-LDL;AS |
| Author Name | Affiliation | E-mail | | GUO Mao-juan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | SUO Yan-rong | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZENG Wen-yun | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YANG Lin | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Hu-hu | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | JIANG Xi-juan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | xijuanjiang@foxmail.com |
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| Abstract
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| [Objective] To observe effect of EGB761 on PON-1 and ox-LDL in rabbits with atherosclerosis. [Methods] Twenty-four Japanese white rabbits were randomly divided into normal group, model group and EGB761 group. Rabbits in normal group were fed with ordinary diet; model and EGB761 group were given high-fat diet for 10 weeks. Meanwhile, from the seventh week, rabbits in EGB761 group were given 50 mg/(kg·d) of EGB761, control group and model group were given normal saline for 4 weeks. Ten weeks later, the vitality and content of PON-1 were detected by Elisa and biochemical methods, the ox-LDL were detected by Elisa method. [Results] Compared with the model group, the vitality and content of PON1 in model group were higher (P<0.05) and the ox-LDL levels were lower, while in EGB761 group the vitality and content of PON-1 increased significantly and ox-LDL decreased obviously (P<0.05). [Conclusion] The effect of EGB761 on reducing the level of ox-LDL in AS rabbits may response to raise the vitality and content of PON-1. |
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