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| Naoxintong extract promotes migration of cardiac stem cells through enhancing expression of CXCR4 |
| Hits 1594 Download times 1845 Received:November 21, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2016.02.08 |
| Key Words
NXT;cardiac stem cells;expression of CXCR4 |
| Author Name | Affiliation | E-mail | | YANG Yue | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Hui-ying | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Lu-sha | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MA Ya-ke | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHAO Bu-chang | Shanxi Buchang Pharma, Xi'an 710082, China | | | JIA Li-fu | Shanxi Buchang Pharma, Xi'an 710082, China | | | ZHAO Jing | Shanxi Buchang Pharma, Xi'an 710082, China | | | CHEN Lu | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Hong | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | wanghongsys@126.com |
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| Abstract
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| [Objective] To study the effect of Naoxintong(NXT) on cardiacstem cell function and to explore its possible mechanism.[Methods] We use real-time RT-PCR array technology, Western-blot ,flow cytometry and transwell methods to investigate the expression of CXCR4 on the cardiac stem/progenitor cell by NXT. [Results] The results showed that the expression of CXCR4 gene and CXCR4 protein in cardiac stem cell were both increased by NXT. [Conclusion] The migration of cardiac stem cell is promoted by NXT through the SDF-1/CXCR4 axis. |
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