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| Anti-platelet aggregation and anti-atrial contractile effect of Guanxinshutong capsule |
| Hits 1430 Download times 4117 Received:December 15, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2016.02.09 |
| Key Words
Guanxinshutong capsule;platelet;aortic ring |
| Author Name | Affiliation | E-mail | | WANG Wei-ming | Research Centre of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin 300100, China | | | XING Xiao-xue | Research Centre of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin 300100, China | | | GAO Hui | Research Centre of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin 300100, China | | | WANG Ling-yan | Research Centre of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin 300100, China | | | LIU Min-na | Research Centre of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin 300100, China | | | FAN Guan-wei | Research Centre of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin 300100, China | fgw1005@hotmail.com |
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| Abstract
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| [Objective] Our explicit objective was to study the function of Guanxinshutong capsule in the treatment of thromboembolic disease. [Methods] We determined the maximal aggregation ratio of Adenosine diphosphate (ADP) and Thrombin-induced platelet aggregation and inhibition rate. We further determined the diastolic ratio and KCl norepinephrine-induced contraction of rat aortic ring. [Results] We found that Guanxinshutong capsule had a potential inhibitory effect on platelet aggregation stimulated by ADP and Thrombin. Furthermore, it was found that Guanxinshutong could inhibit both noradrenaline and KCl-induced contraction of aortic ring and the consequent platelet aggregation. [Conclusion] Guanxinshutong capsule has a definite therapeutic effect against thromboembolic disease. |
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