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| Preparation and evaluation of Tanshinone I solid lipid nanoparticles |
| Hits 2064 Download times 1778 Received:November 18, 2015 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2016.02.12 |
| Key Words
Tanshinone I;solid lipid nanoparticles;preparation;evaluation |
| Author Name | Affiliation | E-mail | | ZHANG Qian | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | | | LIU Zhi-dong | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | lonerlizd@163.com | | QIN Lu | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | | | GU Xing | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | | | FENG Guang-wei | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | |
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| Abstract
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| [Objective] To prepare Tanshinone I solid lipid nanoparticles (TSI-SLN) and investigate the physicochemical properties.[Methods] TSI-SLN were prepared by using emulsion evaporation-solidification method, and the particle size, Zeta potential and encapsulation efficiency(EE) were determined. And the solid-state characterization ofthe TS I-SLN was analyzed by DSC.[Results] The results showed that the TS I-SLN had average particle size of (128±2.00) nm, zeta potential of (-9.35±0.12) mV and the encapsulation efficiency of (74.03±1.32)%, respectively. DSC results indicated that the drug wrapped in nanoparticles completely.[Conclusion] In this paper, emulsion evaporation-solidification method has chosen for the preparation. The TS I-SLN has superior physical and chemical properties |
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