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| The molecular mechanisms of Beta-adrenoceptor signaling pathways in cardiac hypertrophy and the roles of Chinese herbal medicine in regulation of the related pathways |
| Hits 1624 Download times 1703 Received:November 17, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2016.02.18 |
| Key Words
β-adrenergic receptor;myocardial cells;hypertrophy;mechanisms;Chinese herb medicine |
| Author Name | Affiliation | E-mail | | WANG Xing-ye | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GAO Yun-hang | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | NIU Zi-chang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | AI Ju-qing | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CHAI Li-juan | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MAO Hao-ping | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | haoping_mao@126.com |
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| Abstract
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| Cardiac hypertrophy is characterized as increase in size and changes in gene expression of myocardial cells. It's a compensatory response to physiological or pathological stimulation. However, long lasting hypertrophy lead to myocardial cells decompensation which will finally result in heart failure. β-adrenergic receptor (β-AR) is a member of the G protein-coupled receptor(GPCR), which plays a key role in regulation of myocardial function. It involves in the pathways which can induce cardiac hypertrophy. In recent years, more and more studies have demonstrated that Chinese herb medicines regulated cardiac hypertrophy by β-AR pathways. So the present article reviewed the pathways involved in cardiac hypertrophy mediated by β-AR and the regulation of Chinese herb medicines on the related pathways. |
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