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| Effects of Wenxin granule on electrocardiogram and clinical symptoms in adults with atrial premature contractions: A Meta-analysis of randomized controlled trials |
| Hits 2456 Download times 1684 Received:February 20, 2016 |
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| DOI
10.11656/j.issn.1673-9043.2016.03.05 |
| Key Words
Wenxin granule;atrial premature contraction;systematic review;Meta-analysis |
| Author Name | Affiliation | E-mail | | MIAO Peng-wei | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Ming-yan | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Li | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | SHANG Hong-cai | Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | shanghongcai@foxmail.com |
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| Abstract
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| [Objective] To evaluate the effects of Wenxin granule alone or combined with Western medicine on electrocardiogram(ECG) and clinical symptoms in patients with atrial premature contractions(APC). [Methods] We searched six major electronic databases to get RCTs conducted to evaluate the effects of Wenxin granule alone or combined with Western medicine on ECG and clinical symptoms in patients with atrial premature contraction(APC). The methodological quality of the include studies was assessed by criteria from the Cochrane handbook for systematic review of interventions, version 5.2 software. [Results] Sixteen RCTs were included. However, the methodological quality of the studies was generally low. The result indicated that Wenxin granule alone or combined with Western medicine can be more effective in improving the ECG and clinical symptoms in patients with atrial premature contractions .Thirteen of the included studies reported the adverse reaction, such as abdominal distension, nausea, dizziness, Heartbeat bradycardia sinus and so on, and all of the reactions were not severe and disappeared without using any other treatment. [Conclusion] Wenxin granule alone or combined with Western medicine can be more effective in improving the ECG and clinical symptoms in patients with atrial premature contractions. However the low quality of the included studies caused a bad effect on the conclusion which still need high quality studies to demonstrate. |
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