|
| Effects of Heyan Kuntai capsule on monoamine neurotransmitter levels in presenile rats |
| Hits 1490 Download times 1514 Received:February 28, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2016.03.07 |
| Key Words
Heyan Kuntai capsule;natural aging rats;monoamine neurotransmitter |
| Author Name | Affiliation | E-mail | | ZHANG Qing-xia | The Traditional Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG De-qin | The Traditional Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | deqin123@163.com | | HUANG Chun-li | The Traditional Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WEN Jing | The Traditional Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
|
| Abstract
|
| [Objective] To investigate the effects of Heyan Kuntai capsule on monoamine neurotransmitter levels of presenile rats. [Methods] Natural aging method was adopted to establish the presenile rats model. Forty-eight 13 months female SD rats were randomly divided into model group, remifemin group, progynova group, three dose of Heyan Kuntai group, eight in each .Then choose eight of four months female SD rats as youth group. All animals were sacrificed and serum samples were collected after ninety days. The serum levels of orepinephrine (NE), dopamine (DA), hydroxytryptamine (5-HT), 5-hydroxy indole acetic acid (5-HIAA) and the plasma levels of adrenocorticotrophic hormone(ACTH), beta-endorphin(β-EP) were determined by enzyme linked immunosorbent assay (ELISA). [Results] Compared with the model group, Heyan Kuntai capsule markedly increase the serum levels of NE and decrease the serum levels of 5-HT, 5-HIAA and the plasma levels of β-EP was significantly increased and the plasma levels of ACTH was decreased. [Conclusion] Heyan kuntai capsule could regulate the monoamine neurotransmitter levels of presenile rats, and provided an experimental evidence for regulating neuroendocrine functional disorder. |
|
|
|
|
|
