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| Analysis of clinicopathological characteristics and syndromes of traditional Chinese medicine and prognostic factors in breast cancer patients of stageⅠA |
| Hits 2476 Download times 2217 Received:May 23, 2016 |
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| DOI
10.11656/j.issn.1673-9043.2016.04.03 |
| Key Words
breast neoplasms;small tumor;clinicopathological characteristics;syndrome differentiation;prognosis |
| Author Name | Affiliation | | LU Ning | Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China | | LIU Xiao-dong | Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China | | XIE Xiao-juan | Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China | | WANG Xu | Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China |
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| Abstract
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| [Objective] To investigate the relationship between clinicopathological characteristics, syndromes of traditional Chinese medicine (TCM), treatment and prognosis of 156 patients with breast cancer in stage IA. [Methods] Clinical and pathological data of 156 cases of early breast cancer (T1N0M0, I A) were collected and retrospectively analyzed from January 2004 to December 2009 in Tianjin Medical University Cancer Hospital. [Results] Infiltrate ductal carcinoma was the most common pathologic type; Syndrome differentiation of TCM can be divided into syndrome of stagnation of liver qi, disharmony syndrome, dryness toxin accumulation syndrome and Qi and blood deficiency and toxin depression syndrome type. Syndrome of stagnation of liver Qi was the most syndrome type; T1c was the most primary tumor size; Grade II and Grade III were the most histological grades. 5 year PFS was 93.3% and 5 year OS was 99.1%. PFS was related to histological grade and Ki-67 expression and lymphvascular invasion in univariate analysis; Multivariate analysis showed that histological grade and Ki-67 expression were independent prognostic factors for PFS in breast cancer patients with stage I A (T1N0M0). [Conclusion] Although the overall prognosis of breast cancer patients with stage I A (T1N0M0) is better, there was a significant risk of recurrence and metastases in patients in some subgroups who had a poor prognosis. |
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