|
| Cutaneous needle combined traditional Chinese medicine treatment of alopecia areata: a systematic review of randomized controlled trials |
| Hits 1641 Download times 3282 Received:March 15, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2016.04.07 |
| Key Words
Cutaneous needle;alopecia areata;traditional Chinese medicine;systematic review;GRADE system |
| Author Name | Affiliation | E-mail | | LI Qi | Granduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YANG Lin | Granduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZUO Xiao-lin | Granduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | JIN Ying-hui | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MENG Fan-jie | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | mfj127@tjutcm.edu.cn |
|
| Abstract
|
| [Objective] The article is prepared to evaluate the clinical effect of the cutaneous needle combined traditional Chinese medicine treatment of alopecia areata. [Methods] It was included randomized and quasi-randomized controlled trials on Cutaneous needle combined traditional Chinese medicine treatment of alopecia areata. This article we searched China Network Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), Wan Fang Database, SinoMed(CBM), Web of Science, EBSCO, ScienceDirect and PubMed. All searches ended in September 2015. Three independent researchers evaluated the included studies using GRADE profiler3.6.1. The extracted data and assessed were analyzed by RevMan 5.3 and stata 12.0 software with effect estimate presented as relative risk (RR), mean difference (MD) and standardized mean difference （SMD）with a 95% confidence interval (CI). [Results] Twenty-there studies involving 2361 patients were included, and the methodological quality of trials was generally fair in terms of randomization, blinding and intention-to-treat analysis. Meta analyses showed cutaneous needle combined traditional Chinese medicine treatment was superior to medications regarding the total clinical effective rate：[RR=1.26, 95%CI（1.21, 1.31）, P<0.000 1]. The score of lesions integral was decreased[MD= -0.78, 95%CI（-1.5, -0.06）, P=0.03]. The time of patients with improved symptoms was cut down [MD= -19.3, 95%CI（-33.16, -5.43）, P=0.006]. And the recurrence rate was decreased[RR=0.30, 95%CI（0.18, 0.49）, P<0.000 01].There were no serious adverse effects with related to cutaneous needle combined traditional Chinese medicine treatment in the included trials. The two outcomes were moderate quality, two were low quality in the Grade system. [Conclusions] Cutaneous needle combined traditional Chinese medicine treatment to be effective in treatment of alopecia areata. However, further large, rigorous designed trials are warranted. |
|
|
|
|
|
