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| Study on formulation optimization and in vitro release of Icariin/HAP nanoparticle gel |
| Hits 2659 Download times 1933 Received:April 05, 2016 |
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| DOI
10.11656/j.issn.1673-9043.2016.04.11 |
| Key Words
Icariin;nano HAP;orthogonal design;in vitro release |
| Author Name | Affiliation | E-mail | | LIU Meng-meng | College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | JING Hui-xin | College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | BAI Run | College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Yang | College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Department of Experimental Teaching, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | wangy9902@163.com |
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| Abstract
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| [Objective] To optimize the prescription of Icariin/HAP nanoparticle gel and evaluate its in vitro release characteristics. [Methods] The Icariin/HAP nanoparticle suspension liquid was prepared by physical adsorption, Icariin / HAP nanoparticle gel was prepared by grinding method, orthogonal design was used to optimize prescription, dialysis method was developed for the determination of Icariin/HAP nanoparticle gel in the drug release. [Results] The optimum gel was made by carbomer 1%, triethanolamine 1.5%, Propylene glycol 5%, the in vitro release curve of Icariin/HAP nanoparticle gel, Icariin gel and Icariin solution were fitted with pseudo-first-order model and Weibull model. [Conclusion] Using carbomer to make Icariin/HAP nanoparticle gel is simple and stable, can improve the stability of Icariin/HAP nanoparticle suspension liquid. |
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