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| Experimental study on the effect of Shencao Tongmai granule on thrombosis in chronic heart failure rats |
| Hits 1932 Download times 1828 Received:June 18, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2016.05.08 |
| Key Words
Shencao Tongmai granule;chronic heart failure;thrombosis;ATP;BNP;TXB2;PAI-Ⅰ |
| Author Name | Affiliation | E-mail | | SUN Xiao-Hui | Department of Cardiology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China | | | WANG Yi | Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China | | | ZHANG Yan | Department of Cardiology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China | yanzhang1016@126.com |
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| Abstract
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| [Objective] To observe the effect of the pulse of the herb on thrombosis in heart failure rats.[Methods] A total of 80 rats, twenty were randomly selected as the normal control group, the remaining rats by coronary artery ligation method with the exhaustive swimming and diet to make chronic heart failure model, the successful model of the rats were divided into model group, treatment group of Chinese medicine, western medicine treatment group, a total of 4 groups, all with intragastric administration or distilled water for 28 days. Thromboxane B2 were measured by Western blot assay (TXB2), fibrinolytic proenzyme inhibitor (PAI-Ⅰ) and the changes of serum brain natriuretic peptide (brain natriuretic peptide, BNP) for the determination of the concentration of high energy phosphate Colorimetry (adenosine triphosphate, ATP) concentration.[Results] Compared with the normal group, model group and the other groups of rats TXB2, PAI-Ⅰ and BNP levels increased significantly (P<0.01), ATP level were significantly decreased (P<0.01); compared with the model group, Chinese medicine group and Western medicine group TXB2, PAI-Ⅰand BNP content decreased significantly (P<0.01). ATP decreased significantly (P<0.01); TXB2, PAI-Ⅰ of serum in medicine group and Chinese medicine group decreased significantly (P<0.01), no significant difference between the ATP and BNP content (P>0.05).[Conclusion] Shencao Tongmai granule of the traditional Chinese medicine compound can significantly decrease the level of BNP content in rats with heart failure, reduce platelet activation, reduce the incidence of thrombosis after heart failure, can improve mitochondrial energy metabolism, improve heart function, inhibiting or reversing ventricular remodeling. |
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