|
| Effect of ultrafine comminution on ginsenoside dissolution rate in Panax quinquefolium L. |
| Hits 2057 Download times 1911 Received:May 05, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2016.05.11 |
| Key Words
Panax quinquefolium L.;ultrafine comminution;ginsenoside Rg1, Re, Rb1;dissolution rate |
| Author Name | Affiliation | E-mail | | DING Miao-miao | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YANG Kai-lun | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Dong-liang | Dong-E-E-Jiao Co., Ltd., National Engineering Technology Research Center of Glue of Traditional Medicine, Liaocheng 252200, China | | | RU Weng-weng | Dong-E-E-Jiao Co., Ltd., National Engineering Technology Research Center of Glue of Traditional Medicine, Liaocheng 252200, China | | | HUANG Rui | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Zhi-dong | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lonerliuzd@163.com | | LI Nan | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | linan20080402@163.com | | ZHANG Bing | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
|
| Abstract
|
| [Objective] To investigate the effect of ultrafine comminution on ginsenoside dissolution rate in Panax quinquefolium L.[Methods] Vitro dissolution tests were performed, in which homoiothermal water was stirred magnetically and UPLC was used to detect the content of ginsenoside Rb1, Re in ultrafine powder and coarse of Panax quinquefolium L. By calculating cumulative dissolution and making the curves of dissolution rate, the comparison of dissolving rates of powder in ultrafine and coarse was achieved.[Results] The cumulative dissolution of ginsenoside Rb1 in ultrafine powder was higher than in coarse powder. Significant difference (P<0.01) was found between that in ultrafine powder and coarse, while the dissolution rates of ginsenoside Re had no significant different in ultrafine powder and coarse powder. The dissolution rate of ginsenoside Rg1 was not investigated as it's content was too low.[Conclusion] Ultrafine pulverization technology can increase the dissolution rate of ginsenoside Rb1. However, it has no effect on the dissolution rate of ginsenosides Re. |
|
|
|
|
|
