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| Advances on the research of curcumin on the regulation of transcription factors and signal pathways for anti tumor treatment |
| Hits 1651 Download times 1400 Received:June 25, 2016 |
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| DOI
10.11656/j.issn.1673-9043.2016.05.17 |
| Key Words
Curcumin;transcription factor;endoplasmic reticulum stress;autophagy |
| Author Name | Affiliation | | ZHAO Jing-wen | School of Life Sciences, Tianjin University, Tianjin 300072, China |
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| Abstract
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| Curcumin is derived from the dried rhizome of the Curcuma longa plant. Studies have demonstrated that curcumin possesses anti-inflammatory, anticoagulant, antioxidant, hypolipidemic and anticancer properties. In recent years, the anticancer effect of curcumin has gradually become important. Curcumin inhibits the NF-κB and STAT3 signaling pathway in cancer development and progression. It also can inhibit SP-1 and housekeeping gene expression to prevent the formation, migration and invasion of tumor. Recent studies have also found that endoplasmic reticulum stress and autophagy play a role in the apoptosis of cells, and the inhibition of autophagy can increase the endoplasmic reticulum stress mediated by curcumin and its analogs, and further induce apoptosis. In this paper, the effects of curcumin on apoptosis and anti angiogenesis of tumor cells were summarized as follows. |
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