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| Effects of “Modified Bushen Huoxue Decoction” on curative and immunological condition in patients with different types of lupus nephritis |
| Hits 2234 Download times 114 Received:August 26, 2016 |
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| DOI
10.11656/j.issn.1673-9043.2016.06.06 |
| Key Words
"Modified Bushen Huoxue Decoction";lupus nephritis;immunology |
| Author Name | Affiliation | | YUE Ying | 天津中医药大学, 天津 300193
天津市公安医院, 天津 300042 | | JI Yan-wen | 天津医科大学总医院, 天津 300052 | | RUAN Ying-xin | 天津医科大学总医院, 天津 300052 | | ZHANG Mian-zhi | 天津市公安医院, 天津 300042 | | LIU Wei | 天津中医药大学第一附属医院, 天津 300193 | | CHEN Jing | 天津市公安医院, 天津 300042 |
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| Abstract
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| [Objective] To observe the clinical curative efects of "Modified Bushen Huoxue Decoction" on immunological condition in patients with lupus nephritis (LN).[Methods] 102 LN patients were randomly divided into foundation treatment group (n=51) and combined treatment group (n=51);steroids and cyclophosphamide (CTX) or steroids and Mycophenolate Mofeil (MMF) were administered to all patients,while "Modified Bushen Huoxue Decoction" were only administered to patients in the mixed treatment group.After 4-months later,SLE disease activity index score (SLEDAI Score),C3,C4,24 h urine protein quantity,endogenous creatinine clearance rate (Ccr),T lymphocytes subsets (CD3+、CD4+、CD8+) were detected in both groups.[Results] Compaired with foundation treatment group, combined treatment group could significantly elevate Ccr and down-regulate the level of CD8+ T cell (P<0.05). Proliferative LN with combined treatment could significantly elevate Ccr and decrease 24 h urine protein(P<0.05),whereas mixed pathological types of LN elevate Ccr with mixed treatment(P<0.05).[Conclusion] "Modified Bushen Huoxue Decoction" could significantly ameliorate kidney filtration function of LN patients,especially proliferative and mixed pathological types.It also could reduce the applied dose of steroids and immunosuppressants by correcting immune dysfunction. |
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