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| Preparation and in vitro release of curcumin solid lipid nanoparticle |
| Hits 2476 Download times 116 Received:August 30, 2016 |
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| DOI
10.11656/j.issn.1673-9043.2016.06.10 |
| Key Words
curcumin;solid lipid nanoparticle;in vitro release |
| Author Name | Affiliation | E-mail | | LI Chun-hua | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Modern Chinese Medicine Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Zhi-dong | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Modern Chinese Medicine Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lonerliuzd@163.com | | DING Ling-ling | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Modern Chinese Medicine Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HUANG Rui | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Modern Chinese Medicine Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Shu-ya | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Modern Chinese Medicine Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To prepare curcumin solid lipid nanoparticles (Cur-SLN) with glyceryl monostearate as its lipid matrix and study its in vitro release behavior.[Methods] Emulsification-evaporation was used to prepare Cur-SLN and entrapment efficiency was measured by ultracentrifugation method.The properties including particle size and Zeta potential and physical property were measured by laser particle size analyzer and differential scanning calorimetry (DSC),respectively.In vitro release behavior was studied by diameter methods.[Results] Mean diameter and Zeta potential of Cur-SLN were (89.24±2.06) nm and (-18.77±1.27) mV.The mean entrapment efficiency was (89.55±1.84)%.The physical property tested by the DSC was stability,and the in vitro accumulative release until 12 h was (43.12±1.02)%.[Conclusion] Cur-SLN prepared in this study has small size which has an even distribution and satisfactory sustained release efficacy. |
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