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| Effects of Ermiao Pill for different compatibility proportion on the treatment of hyperuricemic rats |
| Hits 1663 Download times 1506 Received:September 25, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2017.01.11 |
| Key Words
Ermiao Pill;compatibility;high uric acid hematic disease |
| Author Name | Affiliation | E-mail | | FAN Ke-tao | Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Traditional Chinese Medicine, Tianjin 300193, China | | | YAN Hai-feng | Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Traditional Chinese Medicine, Tianjin 300193, China | | | DAI Xiang-dong | Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Traditional Chinese Medicine, Tianjin 300193, China | | | XING Lei-lei | Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Yi | Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Traditional Chinese Medicine, Tianjin 300193, China | vip-wangyi@126.com |
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| Abstract
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| [Objective] To investigate the effects of Ermiao Pill for different compatibility proportion on the treatment of hyperuricemic SD rats.[Methods] Using yeast extract 15 g/kg+adenine oxazine 100 mg/kg+oxygen acid potassium 300 mg/kg combination in the preparation of high uric acid hematic disease model in rats. 100 male rats were randomly divided into 10 groups, respectively is the blank group, model group, rhizoma atractylodis, cortex phellodendri, 1:1 group, rhizoma atractylodis, cortex phellodendri, 1:2 group, rhizoma atractylodis, cortex phellodendri, 2:1, rhizoma atractylodis, cortex phellodendri, 1:3 group, rhizoma atractylodis, cortex phellodendri group 3:1 group, the rhizoma atractylodis, cortex phellodendri, 1:0, rhizoma atractylodis, cortex phellodendri 0:1 group, positive drug group (allopurinol 15 mg/kg). Groups respectively ig give rats 1 week in a row, after the last delivery, by detecting the serum concentration of UA, Cre, BUN, serum ALT, AST, T-CHO, TG, HDL, LDL-C-C level, observed in the urine of rats 24 h uua, Cre, BUN, 24 h uv, and quality of liver, kidney and coefficient, evaluation of Ermiao Pill for different compatibility of uric acid.[Results] Compared with model group, Ermiao Pill rate in treatment group and positive medicine group of rats serum uric acid levels were significantly lower (P<0.01), of which highlights 1:2 group effect is significant. Compared with model control group, serum creatinine, 24 h urine (except highlights 1:0 group, positive drug group), 24 h level of uric acid excretion, kidney, kidney coefficient of quality level increased significantly(P<0.05 or P<0.01), urinary creatinine and urea nitrogen levels (except group highlights 3:1), 24 h urine uric acid decreased significantly(P<0.05 or P<0.01). Compared with model group, the proportion of groups and positive medicine group can improve the level of ALT and AST of rats but no significant difference(P>0.05), the quality of the liver and liver coefficient in addition to the positive medicine group were significantly lower than model group(P<0.05 or P<0.01). Compared with model group, in addition to the positive medicine group failed to significantly reduce the TG level (P>0.05), and the rest of the group can significantly reduce the T-CHO, TG, HDL, LDL-C level(P<0.05 or P<0.01).[Conclusion] Ermiao Pill for different compatibility proportion have significantly reduced the high uric acid hematic disease uric acid levels in rats and improve renal uric acid excretion, renal function, the function of regulating blood lipid level. Especially highlights 1:2 group effect is significant, and is superior to other groups. |
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