|
| Determination of equilibrium solubility and apparent oil/water partition coefficient of Glabridin |
| Hits 2124 Download times 2756 Received:October 20, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2017.01.13 |
| Key Words
equilibrium solubility;Glabridin;apparent oil/water partition coefficient |
| Author Name | Affiliation | E-mail | | FENG Qian-ru | Pharmaceutical Department of Guangdong Provincial Hospital of TCM, Guangzhou 510120, China | | | YE Liu-qing | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Yuan-yuan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GONG You-ming | Pharmaceutical Department of Guangdong Provincial Hospital of TCM, Guangzhou 510120, China | | | LI Hong-yan | College of pharmacy, Nankai University, Tianjin 300193, China | | | WANG Yan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | paozhijiaoxue@126.com |
|
| Abstract
|
| [Objective] To determine the equilibrium solubility in different solvents pH buffer solvents.[Methods] Shaking flask method was established to preparing saturated solution of glabridin. HPLC method was used to determine the concentration of glabridin. Apparent coefficient was also determined by shaking flask method and HPLC method.[Results] The maximum solubility of glabridin was in acetone, being 67 862.13 mg/L. The solubility in water was 0.1 mg/L. The apparent oil/water partition coefficient of glabridin was 71 142.16(lgP=4.85).[Conclusion] Glabridin is a soflavones which has moderate-polar. It is soluble in moderate-polar solution and insoluble in water and high lipophilic solution. To elevate the drug concentration and increase bioavailability, the combination of polymers should be considered when peparing external preparation. |
|
|
|
|
|
