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| Effect of Qiming Granule on inflammatory factors and urinary micro albumin in early diabetic nephropathy |
| Hits 1821 Download times 1077 Received:December 04, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2017.02.09 |
| Key Words
Qiming Granule;diabetic nephropathy;inflammatory factor;urinary albumin |
| Author Name | Affiliation | | WANG Jun-yuan | Tangshan City Chinese Medicine Hospital Department, Endocrinology Ward, Tangshan 063000 | | ZHAO Jian-hong | Tangshan City Chinese Medicine Hospital Department, Endocrinology Ward, Tangshan 063000 | | LIU Ying | Tangshan City Chinese Medicine Hospital Department, Endocrinology Ward, Tangshan 063000 | | ZHANG Jun | Tangshan City Chinese Medicine Hospital Department, Endocrinology Ward, Tangshan 063000 | | LI Zhen | Tangshan City Chinese Medicine Hospital Department, Endocrinology Ward, Tangshan 063000 | | ZANG Le-hong | Tangshan City Chinese Medicine Hospital Department, Endocrinology Ward, Tangshan 063000 | | WANG Yu-hong | The 22th Tangshan City Hospital, Medical Ward, Tangshan 063000 |
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| Abstract
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| [Objective] To explore the mechanism of early diabetic nephropathy by observing the effect of Qiming Granule on the inflammatory factors and urinary albumin in early diabetic nephropathy. [Methods] Selected in accordance with the inclusion criteria of patients with early diabetic nephropathy in 120 cases, using the random number table method 60 patients were divided into treatment group and control group of 60 cases, 2 groups were treated with routine treatment and care, the treatment group to the Qiming Granule 1 bag each time, 3 times a day, the control group was given time a day Valsartan capsules 80 mg on the changes of the two groups were observed in patients with hs-CRP, IL-6, IL-1β, TNF-α, and alpha beta 24 h UmAlb after 16 weeks of treatment. [Results] The total effective rate of the treatment group and the control group were 91.67% and 76.67%, and there were significant differences(P<0.05). The two groups before and after treatment in patients with inflammatory factors have improved, but the control group had no statistical significance in hs-CRP, IL-6, IL-1β, TNF-α aspect (P>0.05), the treatment group in hs-CRP, IL-6, IL-1 β and TNF-α comparison with the control group there were significant differences (P<0.05) in 24 h UmAlb group, the groups were statistically significant (P<0.05) before and after treatment, after treatment was not statistically significant(P>0.05). [Conclusion] Qiming Granule in improving early diabetic nephropathy TCM symptoms, inflammatory factors is better than the control group, but also can significantly improve the urinary albumin, can delay the development of diabetic nephropathy. Qiming Granule is safe and effective in the treatment of early diabetic nephropathy, which provides the experimental basis for the clinical application of Qi Ming Granule. |
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