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| Development of mesoporous silica-based nanoparticles with controlled releaseand targeted release capability for cancer therapy with traditional Chinese medicine |
| Hits 2364 Download times 2013 Received:February 09, 2017 |
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| DOI
10.11656/j.issn.1673-9043.2017.03.01 |
| Key Words
mesoporous silica-based nanopartides;cancer;targeted |
| Author Name | Affiliation | E-mail | | LI Nan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Yan | Tianjin Polytechnic University, Tianjin 300387, China | | | GUO Pan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HUANG Rui | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Zhi-dong | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lonerliuzd@163.com |
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| Abstract
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| Mesoporous silica materials have attracted much attention for their potential biomedical applications due to their tailored mesoporous structure,large surface area,good biocompatibility,and the ease of surface functionalization.In this review,we focus on the development of mesoporous silica based nanoparticles,as this type of materials provides a relatively stable material that is amenable to various chemical modifications.We provide an overview of various designs employed to construct MSN-based controlled release systems.These systems respond to internal stimuli such as pH,redox state and the presence of biomolecules as well asto external stimuli such as light and magnetic field.Efforts to develop MSNs with multi-functionality was discussed.Advances in the synthesis of mechanized theranostic nanoparticles open up the possibility to start envisioning future needs for medical equipment. |
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