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| Effects of Qihuang Particles on clinical syndrome in live-kidney deficiency of age-related macular degeneration |
| Hits 1956 Download times 1167 Received:February 10, 2017 |
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| DOI
10.11656/j.issn.1673-9043.2017.03.08 |
| Key Words
age-related macular degeneration (AMD);Qihuang Particles;TCM syndrome |
| Author Name | Affiliation | E-mail | | ZHANG Xin-tong | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIANG Feng-ming | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | liangfm66@163.com | | WANG Li | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Yan | Guangdong Province Traditional Chinese Medical Hospital, Guangzhou, 510000, China | | | LI Hong-mei | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MENG Liang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To observe the clinical effects of Qihuang Particles in liver-kidney deficiency of age-related macular degeneration (AMD).[Methods] All dates were processed by rank sum test,by adopting a pre-and post-treatment pairing study,a total of 120 patients with dry and wet liver-kidney deficiency AMD were randomly divided into Qihuang Particles treatment group (62 cases) and VC control group (58 cases) in order to investigate score changes of vision and TCM syndrome.[Results] On the observe of vision:the differences of the overall vision between before and after treatment of the two groups are no statistically significant (P>0.05).But there are significant differences of the overall vision in the same group before and after contrast (P<0.05).On the observe of TCM syndrome:24 patients show an excellent effect in the Qihuang Particles treatment group,accounting for 38.71%;36 of effective,accounting for 58.06%,and 2 of ineffective,accounting for 3.23%,with an overall response rate (ORR) of 96.77%.Four patients show an excellent effect in the VC control group,accounting for 6.90%;31 of effective,accounting for 53.45%;and 23 of ineffective,accounting for 38.65%,with an ORR of 60.35%.The improvement of TCM syndrome in the treatment group is significantly superior to control group.The difference has statistical significance (P<0.05) compared to pre-and post-treatment between two groups via rank-sum test.Among 45 patients with dry type in the Qihuang Particles treatment group,19 patients show an excellent effect,accounting for 42.22%;24 of effective,accounting for 53.33%;2 of ineffective,accounting for 4.44%,with an ORR of 95.56% while among 17 patients with wet type,5 patients show an excellent effect,accounting for 29.41%;12 of effective,accounting for 70.59%;0 of ineffective,accounting for 0%,with an ORR of 100%.The difference has no statistical significance (P>0.05) compared to dry and wet type of patients via rank-sum test.[Conclusion] Qihuang granule and vitamin C on liver-kidney yin deficiency type of age-related macular degeneration patiengts of vision have a certain improving effect.Qihuang Particles can significantly improve the TCM syndrome in patients with AMD with an excellent clinical effect. |
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