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| The effects of protection of Shenzhujing tablet treatment on MIRI |
| Hits 1577 Download times 1297 Received:March 15, 2017 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2017.04.11 |
| Key Words
Shenzhujing tablet;myocardial ischemia/reperfusion injury;anti-oxidation |
| Author Name | Affiliation | E-mail | | NI Jing-yu | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China
Ministry of Education Key Laboratory of Formula of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Wei-ming | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China
Ministry of Education Key Laboratory of Formula of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Lan | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China
Ministry of Education Key Laboratory of Formula of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FAN Guan-wei | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | fgw1005@hotmail.com |
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| Abstract
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| [Objective] To observe the effects of Shenzhujing tablet treatment on MI/R injury.[Methods] Sixty healthy SD rats were randomly divided into sham control group, model group, verapamil sheet group, and high, medium, low dose group of Shenzhujing tablet. After the pre-dosed 7 d, the rat model of myocardial ischemia/reperfusion was established by ligating the left anterior descending coronary ischemia 30 min, reperfusion 120 min. Cardiac function was evaluated using ultra-high resolution small animal imaging system, LVEF, LVFS, LVIDs, LV Vols, LVIDd, LV Vold were observed; serum MDA, SOD, lactate dehydrogenase (LDH), creatine kinase (CK) were detected.[Results] Shenzhujing tablet 0.18 g/kg may significantly improve ejection fraction (P <0.05), left ventricular shortening fraction (P<0.01),and reducethe level of serum CK (P<0.01); Shenzhujing tablet 0.36 g/kg can reduce the level of serum LDH(P<0.05), MDA(P<0.01), and increase the level of serum SOD(P<0.01).[Conclusion] Shenzhujing tablet can reduce myocardial ischemia/reperfusion damage and improve the cardiac function. |
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