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| The period validity of Cornus Ficinalis by comprehensive weighted scoring method |
| Hits 1479 Download times 1101 Received:May 28, 2017 |
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| DOI
10.11656/j.issn.1673-9043.2017.05.15 |
| Key Words
Cornus Ficinalis;accelerated experiment;sample observation experiment;comprehensive weighted scoring method;validity period |
| Author Name | Affiliation | E-mail | | LIU Ying | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | XIAO Yang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | DUAN Jin-fang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | SONG Hong-wei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | DOU Zhi-ying | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | zhiyingdou@163.com |
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| Abstract
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| [Objective] Explore the validity period of Cornus of ficinalis,to provide experimental basis for its safety and effectiveness of clinical medication.[Methods] The Cornus Ficinalis by accelerated test and sample observation test,determination of loganin in Cornus,morroniside in HPLC,determination of the amount of extract in accordance with the requirement of Pharmacopoeia. Adopt comprehensive weighted scoring method and research contents and extract three index changing with the time,predict the validity of Cornus at room temperature.[Results] Accelerated test for 6 months,Cornus and Fructus Corni decrease rate was 9.3% and 1.07% respectively. the results had no significant change,preliminary prediction of Cornus Ficinalis is valid for 2 years;Fructus Corni long-term test 12 months decline rate is 13.31%,but the total content and extract amount is still in accordance with the standard of Chinese pharmacopoeia.[Conclusion] The accelerated test prediction method of Cornus Ficinalis is valid and feasible,practical and effective period should be based on the specific data for the long-term test. |
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