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| Study on therapeutic effect of compound Diandao gel on rat auricle acne model |
| Hits 1394 Download times 1310 Received:May 18, 2017 |
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| DOI
10.11656/j.issn.1673-9043.2017.05.18 |
| Key Words
compound Diandao gel;adapalene gel;rat auricle acne model;anti-acne effect;dose-effect relationship |
| Author Name | Affiliation | E-mail | | LIN Shan-shan | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | JIN Xin | Department of Pharmacology, Logistics University of Chinese People's Armed Police Force, Tianjin 300309, China | | | HUANG Wei | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Pei-chun | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Rui | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lr_8000@163.com | | NIAN Li | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To explore the therapeutic effect of compound Diandao gel on the rat auricle acne model.[Methods] The rat auricle acne model was made by applying oleic acid to the right auricle of rat for 21 days. After model was established, all rats were divided into normal control group, saline group, adapalene gel group and low-dose, medium-dose, high-dose compound Diandao gel group. These rats were treated with different drugs for 14 days. Then the right auricle of rats was cut out and observed by the naked eye and microscopy. The experimental results were evaluated according to the grading standard for exploring the anti-acne effect of compound Diandao gel.[Results] After the model was established successfully, the skin of the right auricle of the rats was rough and thickened and hardened significantly. The skin was red and swollen, and the skin temperature was elevated. Histopathological observation by microscopy showed obvious pathological changes. After rats were treated with different drugs, the symptoms of auricle acne of rats in adapalene gel group and high-dose compound Diandao gel group were obviously alleviated, and the histological observation showed that auricles were close to normal tissue. The recovery rate of the low-dose group and middle-dose group was lower than that of the high-dose group. The recovery of the adapalene group and every compound Diandao gel groups was significantly better than that of the saline group (P<0.001). However, there was significant difference between low-dose and high-dose compound Diandao group (P<0.05). There was no significant difference between adapalene gel group and medium-dose, high-dose compound Diandao gel group (P>0.05).[Conclusion] Compound Diandao gel on the rat auricle acne model has a good therapeutic effect, and there is a certain dose-effect relationship. |
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