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| Study on the effects of licorice on H2O2-induced H9c2 myocardial injury |
| Hits 1495 Download times 1324 Received:July 01, 2017 |
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| DOI
10.11656/j.issn.1673-9043.2017.06.14 |
| Key Words
licorice;H2O2;H9c2;apoptosis;oxidative stress |
| Author Name | Affiliation | E-mail | | XING Lei-lei | Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China | | | HU Xiao-hui | Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China | | | YANG Jin | Lerentang Pharmaceutical Factory, Tianjin Zhongxin Pharmaceutical Group Co., Ltd., Tianjin 300112, China | | | AI Le | Lerentang Pharmaceutical Factory, Tianjin Zhongxin Pharmaceutical Group Co., Ltd., Tianjin 300112, China | | | WANG Yi | Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China | | | WANG Yan-yan | Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China | wangyywang@yeah.net |
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| Abstract
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| [Objective] To study the effects of licorice on H2O2-induced H9c2 myocardial injury.[Methods] H9c2 cells were treated with H2O2 (100 μmol/L for 4 h) to establish a myocardial injury model, and then treated licorice on the concentration of 400 μg/mL and 800 μg/mL for 4 h. The levels of cell viability, lactic dehydrogenas (LDH), superoxide dismutase (SOD), malondialdehyde (MDA), intracellular reactive oxygen species (ROS), intracellular calcium ion concentration, mitochondrial permeability transition pore (mPTP) and apoptosis rate were measured.[Results] Licorice can improve cell vitality and activity of SOD in different degree, reduce the LDH, MDA, ROS and Ca2+ content, inhibit mPTP opening and apoptosis rate (P<0.05 or P<0.01).[Conclusion] Licorice has the protective effect on H2O2-induced H9c2 myocardial cells. |
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