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| Effect of treatment with Xuebijing injection and its pharmacokinetics markers on serum inflammatory factor indude TNF-α, IL-1, IL-6, IL-8 and IL-10 in rats with sepsis |
| Hits 1839 Download times 1206 Received:September 15, 2017 |
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| DOI
10.11656/j.issn.1673-9043.2018.01.04 |
| Key Words
Xuebijing injection;pharmacokinetics markers;sepsis;inflammatory factor |
| Author Name | Affiliation | E-mail | | SUN Mengjie | Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | TU Yaru | Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | OUYANG Huizi | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | CHANG Yanxu | Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HE Jun | Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | hejun673@163.com |
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| Abstract
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| [Objective] To study the effect of treatment with Xuebijing injection and its pharmacokinetics markers on serum inflammatory factor, indude serum tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), in rats with sepsis.[Methods] Rats were divided into five groups (each 6 rats, n=6) i.e. blank operation, sepsis, sepsis with Xuebijing treatment, Xuebijing pharmacokinetics markers treatment, and levofloxacin treatment group (positive control group). After intravenous injection, sepsis was reproduced in rats by cecal ligation and puncture. Blood samples were collected at 5 h after administration via fossa orbitalis. The concentration of TNF-α, IL-1, IL-6, IL-8 and IL-10 was determined by enzyme linked immunoad sordent assay (ELISA).[Results] The study shows that the concentration of TNF-α, IL-1 and IL-8 were significantly increased in the group of sepsis with Xuebijing treatment, Xuebijing pharmacokinetics markers treatment, and levofloxacin treatment.[Conclusion] Xuebijing injection and its pharmacokinetics markers can inhibit the release of serum inflammatory factorin rats with sepsis. |
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