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| Effect of the tonifying kidney and invigorating spleen on serum pAkt and mTOR in patients with threatened abortion of polycystic ovary syndrome in insulin resistance |
| Hits 1587 Download times 1187 Received:August 20, 2017 |
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| DOI
10.11656/j.issn.1673-9043.2018.01.08 |
| Key Words
the method of tonifying the kidney and strengthening the spleen;polycystic ovary syndrome with insulin resistance;hyperinsulinemia;pAkt;mTOR |
| Author Name | Affiliation | E-mail | | JIANG Sha | Heilongjiang University of Traditional Chinese medicine, Harbin 150040, China | | | JIANG Junzhu | Heilongjiang University of Traditional Chinese medicine, Harbin 150040, China | | | CHEN Lu | First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China | | | FENG Xiaoling | First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China | doctorfxl@163.com |
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| Abstract
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| [Objective] To observe the clinical efficacy of the use of tonifying kidney and invigorating spleen on Polycystic ovary syndrome in insulin resistance(PCOS-IR) patients with threatened abortion,and to further explore its mechanism.[Methods] Elisa method was used to detect the changes of serum hormone (progesterone (P) and human chorionic gonadotropin (β-HCG)), pAkt and mTOR in Polycystic ovary syndrome patients with threatened abortion and healthy pregnant women before and after traditional Chinese medicine treatment.[Results] Before treatment:group A(PCOS in insulin resistance patients with threatened abortion), group B(PCOS without insulin resistance(PCOS-NIR) patients with threatened abortion)compare with C(healthy pregnant women),the levels of pAkt and mTOR were statistically significant (P<0.05). After treatment:compared with group C, the levels of P,β-HCG, pAkt and mTOR in group A and group B had no significant difference in serum (P>0.05),HOMA-IR was significantly lower in group A.[Conclusion] 1) The decrease of pAkt and mTOR levels in serum may be related to the occurrence of threatened abortion in PCOS-IR patients. 2) The method of tonifying kidney and strengthening spleen can improvement of insulin resistance status in PCOS-IR pregnant women,can up regulate the levels of pAkt and mTOR.To provide theoretical basis for further use of pAkt and mTOR related targets in the treatment of threatened abortion patients with PCOS-IR. |
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