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| Clinical study of alopecia areata Qibao Meiran dan treatment of liver and kidney deficiency |
| Hits 1721 Download times 1619 Received:December 23, 2017 |
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| DOI
10.11656/j.issn.1673-9043.2018.01.10 |
| Key Words
Qibao Meiran dan;compound glycyrrhizin;liver and kidney deficiency type;alopecia areata;clinical curative effect;cytokines |
| Author Name | Affiliation | | FAN Hua | Guangxi Guigang City combining traditional Chinese and Western Medicine Hospital Department of Dermatology, Guigang 537100, China | | YAN Yan | Guangxi Guigang City combining traditional Chinese and Western Medicine Hospital Department of Dermatology, Guigang 537100, China | | ZENG Tianqing | Guangxi Guigang City combining traditional Chinese and Western Medicine Hospital Department of Dermatology, Guigang 537100, China |
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| Abstract
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| [Objective] To analyze the expression of clinical efficacy, Qibao Meiran dan treatment of liver and kidney deficiency type of alopecia areata associated cytokine and the effect on quality of life.[Methods] Chosen 62 cases of liver and kidney deficiency alopecia areata patients from Jan. 2016 to Oct.2017, randomly divided into the control group and the observation group, 31 cases each. The control group were treated with oral Compound Glycyrrhizin Tablets + ginger wiped, observation group were treated with oral Qibao Meiran dan + ginger wiped. After 2 months of continuous treatment, the therapeutic effects of the two groups were compared. The percentage of Th17 cells, Treg cells in CD4+T lymphocytes, the levels of cytokines related to serum IL-6 and IL-23, and the quality of life in patients with peripheral blood were compared.[Results] After treatment, the control group was cured in 2 cases, markedly effective in 6 cases, effective in 13 cases, ineffective in 10 cases, the total effective rate was 67.74%, recurrence in 8 cases, the recurrence rate was 25.81%. The observation group was cured in 5 cases, markedly effective in 10 cases, effective in 15 cases, ineffective in 1 cases, the total effective rate was 96.77%, there was no recurrence, there was a significant difference between the two groups (P<0.05). Two groups of patients before treatment of peripheral blood Th17 cells, Treg cells accounted for the percentage of CD4+T cells, there was no significant difference in serum IL-17, IL-6, IL-23 and TGF-α levels (P>0.05); the observation group after treatment of Th17 cells in peripheral blood CD4+T lymphocyte ratio lower than the control group; Treg cells accounted for CD4 percentage of +T cells was higher than that of the control group and there is a statistically significant difference between groups (P<0.05). After treatment, the serum IL-6 and IL-23 levels of the observation group were lower than that of the control group, and there was a statistically significant difference between the two groups (P<0.05). After treatment, the scores of physical function, emotional function, psychological status and social function in the observation group were higher than those in the control group, and there was a statistically significant difference between the two groups (P<0.05). There were no obvious adverse reactions in the two groups during the treatment.[Conclusion] The clinical efficacy of Qibao Meiran dan in the treatment of liver and kidney deficiency type of alopecia areata has great advantages, can regulate the peripheral blood Th17 cells, Treg cell ratio, IL-6, IL-23 and other related regulation of serum cytokine levels, make patients get better quality of life. |
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