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| The effect of Radix Aconiti and Rhizoma Bletillae separately and combined on carrageenan-induced mechanical hyperalgesia on rat |
| Hits 1616 Download times 1241 Received:September 30, 2017 |
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| DOI
10.11656/j.issn.1673-9043.2018.01.12 |
| Key Words
carrageenan;analgesia;laser doppler flowmetry |
| Author Name | Affiliation | E-mail | | PANG Tan | Tianjin University of Traditional Medicine, Tianjin 300193, China | | | LI Xiaojin | Tianjin University of Traditional Medicine, Tianjin 300193, China | | | ZHUANG Pengwei | Tianjin University of Traditional Medicine, Tianjin 300193, China | zhuangpengwei@163.com |
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| Abstract
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| [Objective] To determine the effect of of Radix Aconiti and Rhizoma Bletillae separately and combined on carrageenan-induced mechanical hyperalgesia on rat.[Methods] Thirty-four male SD rats were randomly divided into 5 groups:Normal group (n=4), Model group (n=6), Radix Aconiti group (n=8), Rhizoma Bletillae group (n=8) and Radix Aconiti-Rhizoma Bletillae combined group (n=8) 0.1 mL carrageenan solution was injected into the left hind paw of all rats except the normal group. The 5 groups were separately dosed with saline, saline, Radix Aconiti extraction (2.25 mg/kg), Rhizoma Bletillae extraction (2.25 mg/kg) and Radix Aconiti-Rhizoma Bletillae extractions combined (2.25 mg/kg+2.25 mg/kg) 1 h post the carrageenan injection. Mechanical hyperalgesia was measured by the paw-pressure test (analgesimeter, Ugo Basile, Italy), Blood flow was measured by Laser Doppler Flowmetry at 1 h and 3 h post the test reagent dosed.[Results] Single dosing of Radix Aconiti extraction (2.25 mg/kg) has significant analgesic effects. Single dosing of Rhizoma Bletillae extraction (2.25 mg/kg) can decreased the blood flow of the inflammation paw. Radix Aconiti-Rhizoma Bletillae extractions combined (2.25 mg/kg+2.25 mg/kg) has analgesic effects and can decreased the blood flow of the inflammation paw.[Conclusion] Radix Aconiti extraction has analgesic effects and Rhizoma Bletillae extraction can decreased the blood flow. When they were dosed combined, don't influenced the other. |
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