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| Comparative study on the absorption of puerarin in the nasal circulation of Tongqiao stasis nasal drops and Tongqiao microemulsion |
| Hits 1790 Download times 1296 Received:September 02, 2017 |
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| DOI
10.11656/j.issn.1673-9043.2018.01.16 |
| Key Words
Tongqiao nasal drops;Tongqiao microemulsion;puerarin;irritation;in vivo nasal circulation perfusion |
| Author Name | Affiliation | E-mail | | JIA Shan | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100102, China | | | ZHANG Ziwei | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100102, China | | | SUN Ruyu | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100102, China | | | ZHENG Mengcheng | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100102, China | | | YANG Bing | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100102, China | | | DU Shouying | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100102, China | dushouying@263.net | | LU Yang | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100102, China | landocean28@163.com | | BAI Jie | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100102, China | | | LI Pengyue | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100102, China | |
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| Abstract
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| [Objective] This study intends to study the irritation of Tongqiao nasal drops and Tongqiao microemulsion, and compare Tongqiao nasal drops and blood stasis Tongqiao microemulsion nasal absorption rate in rats.[Methods] This study compared irritating Tongqiao nasal drops and Tongqiao microemulsion by using toad palate cilia experiment. Study on nasal absorption characteristics of active component of puerarin in Tongqiao stasis nasal drops and Tongqiao microemulsion in rats by volume correction method in rats with nasal circulation.[Results] The results showed that irritation of Tongqiao nasal drops than Tongqiao microemulsion. The results showed that the rate constant of puerarin in the Tongqiao stasis nasal drops was (3.658±0.25)×10-3/min, and the rate constant of puerarin in the microemulsion was (2.732±0.29)×10-3/min. The nasal absorption of puerarin in Tongqiao nasal drops and Tongqiao microemulsion was consistent with the first-order rate process, which was the result of passive absorption.[Conclusion] Compared with the Tongqiao microemulsion in nasal absorption of Puerarin, Tongqiao nasal drops is faster than microemulsion, but microemulsion is low irritation, as Tongqiao microemulsion nasal preparation development provides a certain basis for a new dosage. |
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