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| Application of fuzzy comprehensive evaluation method in optimization of dandelion gelatin prescription |
| Hits 1688 Download times 1191 Received:December 22, 2017 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2018.02.14 |
| Key Words
fuzzy comprehensive evaluation;gelatin;subjective index;objective index |
| Author Name | Affiliation | E-mail | | ZHANG Zhe | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 300193, China | | | WANG Yajing | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 300193, China | Yajing022@163.com | | ZHOU Hao | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 300193, China | | | TIAN Qianyu | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 300193, China | | | SHI Huishu | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 300193, China | | | WANG Yanan | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 300193, China | | | LI Jinling | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin 300193, China | |
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| Abstract
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| [Objective] To investigate the accuracy and effect of fuzzy comprehensive evaluation in the evaluation of dandelion gelatin, so as to provide more accurate and effective evaluation methods for external use of new dosage forms.[Methods] The optimal formulation design, setting of gelling agent (Carbopol-940), surfactant (PEG-40 hydrogenated castor oil) and emollients (isononanoic acid isononyl) dosage of three factors as independent variables, in the optimization process, the application of fuzzy comprehensive evaluation method for subjective index of dandelion (appearance, skin gel sense) and objective index (viscosity) were evaluated. Results:The optimal prescription for-940 carbomer gel 0.138 g, PEG-40 hydrogenated castor oil 0.801 g, isononanoic acid isononyl ester compound 0.244 g, moisturizing agent 2.62 g, antioxidant 0.02 g, drug loading of 1 g. The dandelion gel prepared according to the optimum prescription has a uniform appearance, a good skin feeling and a viscosity of 2 280 mPa/s. The average of the comprehensive score is 4.244, and the deviation is 4.230 less than the predicted value of 1%.[Conclusion] The fuzzy comprehensive evaluation method can evaluate the main and objective indexes of gel at the same time, and the result is high accuracy and good repeatability. |
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