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| Research progress on toxicity and attenuated synergies by pharmaceutics technology of Strychnos |
| Hits 1635 Download times 1215 Received:March 30, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2018.03.05 |
| Key Words
strychnos;chemical constituents;pharmacological effect;toxicity;attenuated synergies;pharmaceutics technology |
| Author Name | Affiliation | E-mail | | GUO Pan | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Xinyue | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Bing | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LU Peng | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Jiawei | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Zhidong | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lonerliuzd@163.com |
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| Abstract
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| Strychnos has exact clinical efficacy, and is widely used in treating rheumatism, numbness paralysis, rheumatoid arthritis and other diseases. However, the application is limited due to the toxic reactions. Therefore, to attenuate the toxicity and enhance the efficiency will be of great significance to strychnos. In this paper, the pharmacological effect, toxicity and the method of attenuating the toxicity and enhancing the efficiency through pharmaceutics technology were summarized, which provided the basis for further study. |
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