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| Effects of Panax Notoginseng Saponins microemulsion on behavior and striatal dopamine content in Parkinson's model rats |
| Hits 1712 Download times 1285 Received:February 14, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2018.03.15 |
| Key Words
Panax notoginseng saponins;Parkinson;behavior;dopamine |
| Author Name | Affiliation | E-mail | | REN Jing | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | | | WU Yumei | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | | | MA Li | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | | | CHANG Mengchun | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | | | LIU Boying | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | | | ZHANG Lina | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | | | LIU Zhidong | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | Lonerliuzd@163.com |
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| Abstract
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| [Objective] To study the effective onset time of panax notoginseng saponin microemulsion on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson's mouse model, which is lay the fundation of the pharmacokinetics and PK-PD study.[Methods] First, MPTP-induced mouse model of Parkinson's disease was injected intraperitoneally with MPTP (30 mg/kg) for 5 days. On the third day after the model was given, Panax notoginseng microemulsion and solution (100 mg/kg) were given MPTP-induced Parkinson's model rats. After the last day of administration behavioral tests index, the next day after the behavioral experiments in each group decapitation brains were removed by HPLC-Determination of Dopamine in a fluorescence detector.[Results] Mice MPTP induced Parkinson in which significant behavioral disorders; Panax notoginseng saponins microemulsion and solution treatment group, a slight improvement in behavioral disorders. Compared with the normal group, the dopamine content in the model group was significantly lower (P<0.01), the dopamine content in the PNS microemulsion and solution administration group was significantly higher (P<0.01), and there was a significant difference between the two groups (P<0.01).[Conclusions] Panax notoginseng saponins microemulsion on the Parkinson model mice have a significant therapeutic effect, he effect of Panax notoginseng microemulsion group was better than that of solution group. |
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