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| Pharmacological research and application progress of tetrandrine in treating idiopathic pulmonary fibrosis |
| Hits 1415 Download times 1374 Received:January 25, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2018.03.21 |
| Key Words
tetrandrine;tissues fibrosis;idiopathic pulmonary fibrosis |
| Author Name | Affiliation | E-mail | | SHANG Lu | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Affiliated Hospital of Logistics University of Chinese People's Armed Police Force, Tianjin 300162, China | | | DONG Yan | Affiliated Hospital of Logistics University of Chinese People's Armed Police Force, Tianjin 300162, China | dongyanwj@163.com | | LIU Bin | Affiliated Hospital of Logistics University of Chinese People's Armed Police Force, Tianjin 300162, China | | | WEI Luqing | Affiliated Hospital of Logistics University of Chinese People's Armed Police Force, Tianjin 300162, China | | | DONG Min | Affiliated Hospital of Logistics University of Chinese People's Armed Police Force, Tianjin 300162, China | |
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| Abstract
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| Pulmoary fibrosis is the final outcome for a variety of interstitial lung disease,and there is no effective treatment. Tetrandrine (Tet) is the main alkaloid isolated from the lumpy root of Stephania tetrandra,and has shown good anti-fibrosis effect in the treatment of silicosis, with low price and few side effects. this paper is intended to summarize the main mechanism of tetrandrine anti-fibrosis,including:uppressing inflammatory reaction; improving oxidative stress; affecting cell apoptosis; interventing the expression of TGF-β1. meanwhile, the clinical reports of tetrandrine in the treatment of idiopathic pulmonary fibrosis in recent years were introduced, which provided theoretical basis for clinical application. |
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