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| Metabolomics in the diagnosis of coronary heart disease with phlegm and blood stasis syndrome |
| Hits 2926 Download times 1568 Received:April 20, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2018.04.01 |
| Key Words
coronary heart disease;phlegm and blood stasis;metabolomics;biomarkers |
| Author Name | Affiliation | E-mail | | CAI Xuemeng | Tianjin University of Traditional Chinese Medicine, Tianjin 300139, China | | | WANG Shuo | Tianjin University of Traditional Chinese Medicine, Tianjin 300139, China | | | GAO Shan | Tianjin University of Traditional Chinese Medicine, Tianjin 300139, China | | | LI Lin | Tianjin University of Traditional Chinese Medicine, Tianjin 300139, China | | | LI Yubo | Tianjin University of Traditional Chinese Medicine, Tianjin 300139, China | yuboli1@163.com | | YU Chunquan | Tianjin University of Traditional Chinese Medicine, Tianjin 300139, China | ycq-4@163.com |
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| Abstract
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| Invasive coronary angiography and its side effects severely limit the screening and early risk prediction of large-scale coronary heart disease in the course of clinical treatment of coronary heart disease with phlegm and blood stasis syndrome.The extensiveness and intractability of coronary heart disease with phlegm and blood stasis syndrome and the subjectivity of differentiation of syndromes and treatment have affected the efficacy of Chinese medicine in treating coronary heart disease.The emergence of metabolomics solved this problem and penetrated the concept of precision medicine into the whole process of traditional Chinese medicine diagnosis and treatment. Through the research and study on the literature of metabolomics in the databases of Zhiwang, Wanfang, Weipu,Pubmed, Elsevier, etc. in the application of coronary heart disease, it was found that the diagnosis of coronary heart disease involves phospholipid metabolism, energy metabolism, metabolism of unsaturated fatty acids and their metabolites and intestinal microflora. The metabonomics of coronary heart disease syndrome of phlegm and blood stasis involves metabolism of glucose and lipids, energy metabolism and so on. |
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