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| The research progress on effects of diester-diterpenoid alkaloidson metabolic enzymes and myocardial toxicity of Fuzi |
| Hits 1580 Download times 1152 Received:April 15, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2018.04.03 |
| Key Words
Fuzi;diester diterpenoid alkaloids;myocardial toxicity;cytochromes P450;compatibility |
| Author Name | Affiliation | E-mail | | SUN Yan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Yu | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Jinghua | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Siwei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Xiaoying | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | wxy@tjutcm.edu.cn |
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| Abstract
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| Fuzi is a commonly used Chinese herbal medicine with a wide range of pharmacological effects, but the cardiotoxicity was significant. Its main toxic components are diester diterpenoid alkaloids, such as aconitine, hypaconitine and mesaconitine. How to reduce Fuzi toxicity without affecting drug efficacy is particularly important. Over the years, many scholars have been studying in depth the toxicity mechanism of alkaloids in Fuzi and achieved a certain degree of consensus. By summarizing domestic and foreign research data, this article describes the effects of diester-diterpenoid alkaloids contained in Fuzi on cytochrome P450 enzymes, as well as the oxidative damage, apoptosis, gap junction protein Cx43, and Na+, K+,Ca2+ homeostasis of the myocardium associated with its cardiotoxicity. The mechanism of compatibility of Fuzi-Gancao, Fuzi-Renshen associated with the above mechanisms are described. |
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