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| Huanglian Wendan decoction on phlegm heat metabolic syndrome clinical curative effect observation |
| Hits 1874 Download times 1203 Received:February 25, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2018.04.06 |
| Key Words
Huanglian Wendan decoction;phlegm heat syndrome;metabolic syndrome;insulin resistance;inflammatory factor |
| Author Name | Affiliation | E-mail | | JIANG Yuepeng | Meilongjiang Univeresty of Traditional Chinese Medicine, Harbin 150040, China | | | LIU Jianchao | Meilongjiang Univeresty of Traditional Chinese Medicine, Harbin 150040, China | | | LI Zhihao | Meilongjiang Univeresty of Traditional Chinese Medicine, Harbin 150040, China | | | HU Huijun | Meilongjiang Univeresty of Traditional Chinese Medicine, Harbin 150040, China | | | ZHAO Zhicheng | The First Affiliated Hospital of Heilongjiang University of Tradition Chinese Medicine, Harbin 1500400, China | 47306702@qq.com |
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| Abstract
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| [Objective] To study the effect of Jiawei Huanglian Wendan decoction combined with routine therapy on insulin resistance and inflammatory factors in patients with metabolic syndrome.[Methods] Fouty-eight patients with metabolic syndrome were randomly divided into control group (basic treatment) 24 cases and treatment group (basic treatment plus modified Huanglian Wendan decoction) 24 cases, the course of treatment was 2 weeks. The measurement indexes before and after treatment body; fasting blood glucose (FPG) and 2 h postprandial blood glucose (2h PG), glycosylated hemoglobin (Hb A1c), fasting insulin (FINS) and insulin resistance index (HOMA-IR), blood lipid and interleukin-6 (IL-6), interleukin-10 (IL-10) etc.[Results] After treatment, the body mass index (BMI), waist hip ratio (WHR), FPG, 2 h PG, Hb A1c, FINS and HOMA-IR than the control group (P<0.05); compared with the control group, the treatment group after treatment of triglyceride (TG), total cholesterol (TC), Low density lipoprotein (LDL-C) levels were significantly lower (P<0.05), high density lipoprotein (HDL-C) levels were significantly increased (P<0.05); after treatment, the treatment group IL-6 significantly decreased, IL-10 level increased significantly (P<0.05). The treatment period, the treatment group and the control group showed no adverse reaction.[Conclusion] Jiawei Huanglian Wendan decoction Combined with conventional treatment can better improve metabolic function in patients with metabolic syndrome, and the safety is good. |
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