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| Mechanisms of Simiao Yongan deooction on heart failure predicted by network pharmacology |
| Hits 1924 Download times 1260 Received:February 26, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2018.04.17 |
| Key Words
Simiao Yongan deooction;heart failure;network pharmacology;mechanism |
| Author Name | Affiliation | E-mail | | REN Yinglu | School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China | | | ZHANG Huimin | School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China | | | LIU Jinying | School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China | | | SU Congping | School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China | | | WANG Qing | School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China | | | WANG Wei | School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China | | | GUO Shuzhen | School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China | guoshz@bucm.edu.cn |
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| Abstract
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| [Objective] This study was designed to screen the targets of bioactive ingredients of Simiao Yongan decoction(SMYAD), and investigate the "disease——multitargets-multicomponents" intervention mechanism of SMYAD on Heart failure.[Methods] The main targets of the active ingredients of SMYAD were filtrated based on the bioinformatics analysis tool (BATMAN-TCM). Cytoscape software was used to build the ingredients-targets network of SMYAD on heart failure.[Results] It showed 89 active ingredients and 15 targets involving heart failure in SMYAD, and a good interaction between them was supported by the score. The 15 targets were mainly associated with ACE、ADRA2A、ADRA2B and so on.[Conclusion] These effects of SMYAD improved the heart function may be related to the reduction of Angiotensin Ⅱ, inhibition of Renin angiotensin system (RAS) activity, regulation of sympathetic nervous system and catecholamine system,etc.The factors of honeysuckle have the most significant influence on SMYAD treating heart failure. |
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