|
| The effect of Xuanfu Daizhe decoction on inflammations in Reflux Esophagitis rats of CAP |
| Hits 1321 Download times 980 Received:April 05, 2018 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2018.05.10 |
| Key Words
Xuanfu daizhe decoction;CAP;reflux esophagitis;inflammations |
| Author Name | Affiliation | E-mail | | HUANG Yan | Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China | | | XU Mingying | Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China | | | XIA Xuejiao | Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China | | | ZHANG Junjie | Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China | zhangjunjie70@aliyun.com |
|
| Abstract
|
| [Objective] Observed the content of TNF-α, IL-1β, IL-6 and IL-10 in esophageal tissue and plasma of reflux esophagitis (RE) rats, to explore the protection mechanism of Xuanfu daizhe decoction.[Methods] Rats were randomly divided into normal group, the RE group, control group, model group, Chinese medicine and western medicine group. The Model group were administered "left cervical vagotomy" and "cardiomyotomy combine with pylorus ligation". After 3 weeks, each rats were treated with the corresponding drug for 2 weeks, the rats were sacrifice, collected the esophageal tissue and plasma. Observed the pathological morphological changes of each rats esophageal tissue.Using ELISA method to detect TNF-α, IL-1β, IL-6 and IL-10 levels in esophageal tissue and plasma.[Results] The esophageal mucosal inflammation in Chinese medicine group obviously improved compared with model group, the content of TNF-α, IL-1 beta, IL-6 in Chinese medicine group were lower than the model group (P<0.05 or P<0.01), the content of TNF-α, IL-1β in plasma, compared with model group, there was no significant difference (P>0.05). The content of IL-10 in Chinese medicine group compared with model group, there was no statistical difference.[Conclusion] Xuanfu daizhe decoction can improve RE rats' esophageal mucosal inflammation, by decreasing the content of TNF-α, IL-1β and IL-6 in esophageal tissue, but have no effect on IL-10 levels. |
|
|
|
|
|
