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| Preparation and evaluation of Tongqiao Sanyu microemulsion |
| Hits 1646 Download times 1038 Received:March 25, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2018.05.12 |
| Key Words
Tongqiao Sanyu prescription;microemulsion;pseudo-ternary phase diagram;irritation;drug loading |
| Author Name | Affiliation | E-mail | | JIA Shan | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100029, China | | | ZHANG Ziwei | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100029, China | | | TAN Jiawei | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100029, China | | | YANG Bing | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100029, China | | | 白洁 | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100029, China | | | 李鹏跃 | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100029, China | | | DU Shouying | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100029, China | dushouying@263.net | | 陆洋 | Beijing University of Chinese Medicine, College of Traditional Chinese Medicine, Beijing 100029, China | landocean28@163.com |
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| Abstract
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| [Objective] The experiment is to prepare Tongqiao Sanyu microemulsion, and investigate its content, physical,chemical properties and irritation.[Methods] Use the solubility of puerarin as an index, investigate the appropriate emulsifier, co-emulsifier and oil phase. And then through the pseudo ternary phase diagram, optimize the microemulsion prescription.[Results] The formulation is EL35-1, 2-propanediol-IPM-water, and the ratio is 29.23:29.23:5.18:36.34 (W:W:W:W). System of Tongqiao Sanyu microemulsion for the O/W microemulsion, the appearance of clear and transparent, The pH is 5.31. Placed under the transmission electron microscope observation, round, uniform.. The average particle size was 17.86 nm and the zeta potential was -4.90 by laser particle size analyzer. The dose of Puerarin was 68.64 mg/g, and paeoniflorin was 26.96 mg/g.Toad palate cilia irritation test results show that the drug suspension and microemulsion preparations are certain irritation.[Conclusion] Results show that Tongqiao Sanyu microemulsion can significantly improve the insoluble drug puerarin drug loading, and the formation of uniform and stable system. Tongqiao Sanyu microemulsion can provide a new dosage form for Tongqiao Shuyu recipe. The irritation of microemulsion is less than that of the solution, and the damage of microemulsion is reversible |
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