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| Antihypertensive effects of Qinggan Tongluo yin in spontaneously hypertensive rats and protective effect on SHR heart |
| Hits 1725 Download times 1405 Received:March 24, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2018.05.14 |
| Key Words
Qinggan Tongluo yin;Tianma Gouteng decoction;essential hypertension;professor XU Zongpei |
| Author Name | Affiliation | E-mail | | SHA Zhengmei | Tianjin University of Traditional Chinses Medicine, Tianjin 300193, China | | | XU Zongpei | Tianjin University of Traditional Chinses Medicine, Tianjin 300193, China | | | LI Jinghao | Tianjin University of Traditional Chinses Medicine, Tianjin 300193, China | | | WANG Hongtao | Tianjin University of Traditional Chinses Medicine, Tianjin 300193, China | | | LI Lin | TCM Resarch Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Hong | TCM Resarch Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Linwei | Tianjin University of Traditional Chinses Medicine, Tianjin 300193, China | | | YANG Pengfei | Tianjin University of Traditional Chinses Medicine, Tianjin 300193, China | | | LI Yuhong | TCM Resarch Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | yhltcm@126.com |
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| Abstract
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| [Objective] Qinggan Tongluo yin(QGTLY) is a clinical experience based on professor XU Zongpei. To study the effects of QGTLY to spontaneously hypertensive rats (SHR) blood pressure, cardiac function and morphology, blood lipid.[Methods] By using SHR,measure blood pressure SBP on 1, 3, 4, 6 hours after the rat was tread with QGTLY one time, measure blood pressure SBP on 10 weeks after the rat was tread with QGTLY continuously. The indicators of left ventricular function and morphological structure were measured by small animal ultrasonic measuring instrument, such as LVEF, LVFS, Lvid, Ivs etc. Observe the changes of treated with QGTLY continuously on 10 weeks to study the effects on lipid.[Results] Treating with different dose group of QGTLY one time can not reduce the SBP of SHR. Treating with different dose group of QGTLY continuously 10 weeks. Treating with QGTLY[25 g/(kg·d)] redue the SBP of SHR at 1weeks, 5 weeks(P<0.05~0.01). Treating with QGTLY[6.25g/(kg·d)] reduce the SBP of SHR at 1 weeks, 7 weeks, 8 weeks(P<0.05). Treating with Valsartan one time or continuously 10 weeks can reduce the blood SBP(P<0.05~0.01). Different dose group of QGTLY can improve the EF, FS(P<0.05~0.01), reduce the left ventricular systole(P<0.05~0.01) and the end volume of the left ventricle(P<0.05~0.01), increase the interventricular septum thickness(P<0.01). There were no changes in lipids.[Conclusion] QGTLY can improve cardiac morphology, increase cardiac function, and reduce left ventricular hypertrophy on SHR. |
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