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| The role of mTOR signal pathway in coronary heart disease and research progress of traditional Chinese medicine intervention |
| Hits 2189 Download times 2019 Received:September 11, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2018.06.01 |
| Key Words
coronary heart disease;mTOR;energy metabolism;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | LI Jie | Guang'an men Hospital China Academy of Chinese Medical Sciences, Beijing 100053, China | | | LIU Ruxiu | Guang'an men Hospital China Academy of Chinese Medical Sciences, Beijing 100053, China | liuruxiu@163.com |
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| Abstract
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| Coronary heart disease ranks first in the top ten causes of death and its prevention and treatment is a thorny issue facing the medical community. Currently in the treatment of myocardial ischemia in people pay more attention to the coronary artery by interventional or thrombolytic method, but myocardial energy metabolism is also induced or aggravated myocardial ischemia is an important factor. Therefore, to study myocardial energy metabolism pathway and regulate it effectively, or to improve myocardial metabolism through drugs is another effective strategy for the treatment of ischemic heart disease. The central regulator of mammalian mammalian target of rapamycin (mTOR) cell nutrition induction and growth can sense the energy status and regulate its downstream signaling pathways to regulate cell metabolism and cell cycle progression and cell growth. This review summarizes the role of mTOR signaling pathway in the pathogenesis and progression of coronary heart disease and the regulatory role of Chinese medicine. |
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