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| Effect of Shenmai injection against doxorubicin cardiotoxicity and its antitumor effect combined with radiotherapy or chemotherapy |
| Hits 1561 Download times 1124 Received:October 10, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2018.06.02 |
| Key Words
Shenmai injection;doxorubicin;cardiotoxicity;synergistic antitumor |
| Author Name | Affiliation | E-mail | | YANG Dongli | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | XU Zongpei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Yuhong | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin 300193, China | | | LI Jinghao | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Hongbo | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Lin | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin 300193, China | einnie_li27@sina.com |
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| Abstract
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| Shenmai injection, which is derived from Shengmaisan in Qianjin Yaofang, is widely used in the clinical treatment of coronary heart disease, viral myocarditis, chronic pulmonary heart disease, etc. In recent years, clinical and experimental studies successively reported the effect of Shenmai injection against doxorubicin cardiotoxicity. Its mechanism involves several aspects, including scavenging free radical, relieving calcium overload and protecting mitochondria. In addition, many studies have indicated that Shenmai injection can enhance the antitumor efficacy of radiotherapy or chemotherapy. It is suggested that Shenmai injection plays a vital role in the treatment of tumor, with the strengthening body resistance and eliminating evil Shenmai injection, which is derived from Shengmai san in Qianjin Yaofang, is widely used in the clinical treatment of coronary heart disease, viral myocarditis, chronic pulmonary heart disease, etc. In recent years, clinical and experimental studies successively reported the effect of Shenmai injection against doxorubicin cardiotoxicity. Its mechanism involves several aspects, including scavenging free radical, relieving calcium overload and protecting mitochondria. In addition, many studies have indicated that Shenmai injection can enhance the antitumor efficacy of radiotherapy or chemotherapy. It is suggested that Shenmai injection plays a vital role in the treatment of tumor, with the strengthening body resistance and eliminating evil efficacy, which mechanism is worthy of further explored. |
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