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| The impact of pterostilbene on transforming NF-κB/TGF-β1/smad3 signaling pathway of pulmonary fibrosis in rats |
| Hits 1494 Download times 1129 Received:May 14, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2019.01.15 |
| Key Words
Pterostilbene;pulmonary fibrosis;NF-κB/TGF-β1/smad3 |
| Author Name | Affiliation | E-mail | | PENG Yanfang | Zhongnan Hospital of Wuhan University, Wuhan 430071, China | | | ZHANG Yingweng | Zhongnan Hospital of Wuhan University, Wuhan 430071, China | hhao3838@sina.com | | ZHAO Yingqian | Hubei University of Traditional Chinese Medicine, Wuhan 430065, China | | | WANG Xiuping | Zhongnan Hospital of Wuhan University, Wuhan 430071, China | | | AI Wang | Wuhan University, Wuhan 430071, China | |
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| Abstract
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| [Objective] To study the mechanism of pterostilbene which treatpulmonary fibrosis induced by bleomycin-inducedin rats.[Methods] A single dose of bleomycin was intratracheal injected into the SD rats to induce PF. After injection of bleomycin,the rats were randomly divided into prednisone group,low and highdose Pterostilbene treatment groups and model group. The rats that were instilled with normal saline intratracheally served as the blank group. After the treatment for 28 d,the pulmonary pathologic changes were observed under microscope with hematoxylin-eosin staining. The serum levels of NF-κB,TGF-β1 were determined by enzyme-linked immunosorbent assay (Elisa). The immunohistochemical staining was adopte expressions of TGF-β1 and smad3 in each group.[Results] In Pterostilbene groups of high dose,the expression of TGF-β1,smad3,NF-κB isweakened.[Conclusion] Pterostilbenehas a certain treatmenteffect on the pulmonary fibrosis induced by bleomycin in rats,possibly through controlling NF-κB/TGF-β1/smad3 expression. |
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