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| Study on the preparation process of compound Rhodiola crenulata dropping pill |
| Hits 2065 Download times 1266 Received:January 05, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2019.01.21 |
| Key Words
Compound Rhodiola;orthogonal test;salidroside;extraction technology |
| Author Name | Affiliation | E-mail | | ZHENG Lujing | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China | | | LIU Qinghuan | Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China | | | TAO Zunwei | Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China | taozunweitj@163.com |
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| Abstract
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| [Objective] To screen and optimize the best extraction technology of compound Rhodiola. The preparation method of dropping pills of this prescription is preliminarily explored.[Methods] The process was designed by orthogonal experimental method. Taking the content of salidroside and recovery rate of dry ointment as indexes to optimize 4 factors which includes extraction time,ethanol concentration,extraction times and solvent multiple. Studying condensing agent,matrix and its ratio,drugs and matrix proportion and optimize the molding process.[Results] The results of variance analysis showed that the extraction time,extraction times and solvent multiple had significant impact on the preparation.The optimum extraction process was adding 10 fold amount of 60% ethanol,extracting for 1.5h and 2 times. The average content of salidroside in the test was 1.73%,RSD=1.2% and the yield of dry extract was 24.28%,RSD=1.6%(n=3). Dimethyl siliconeoil was selected as condensing agent. The best ratio of PEG4000 and PEG6000 was 2:1. The ratio of drug to matrix was 1:2.5. [Conclusion] The extracting and molding process of the optimized compound Rhodiola is reasonable,stable and feasible. |
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