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| Integrated traditional Chinese and western medicine for the Non-motor symptoms of parkinson's disease: a systematic review and meta-analysis |
| Hits 1764 Download times 1187 Received:December 11, 2018 |
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| DOI
10.11656/j.issn.1673-9043.2019.02.12 |
| Key Words
parkinson's disease;non-motor symptoms;integrated Chinese and Western Medicine;systematic review;meta analysis |
| Author Name | Affiliation | E-mail | | TIAN Haolin | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | TIAN Jinzhou | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | NI Jingnian | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | LI Ting | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | WEI Mingqing | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | ZHANG Xuekai | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | ZHANG Tianqing | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | ZHOU Mengling | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | ZHOU Hufang | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | JIA Dongdong | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | WEI Xinru | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | LIN Leying | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | ZHA Mu | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | YAO Xuan | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | LIANG Junjie | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | SHI Jing | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | shijing87@hotmail.com |
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| Abstract
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| [Objective] To systematicallyevaluate the efficacy and safety ofintegrated Chinese and Western medicine in the treatment ofnon-motor symptomsof Parkinson's disease.[Methods] The Chinese and English databases were searched comprehensively. Self-built library to collect all in June,2018 traditional Chinese medicine with western medicine treatment with western medicine basis therapy (and Chinese medicineplacebo) clinical randomized controlled trials. According to the inclusion criteria and exclusion criteria,choose to conform to the standards of the related literature and extract data,on the basis of the Cochrane faced to quality assessment of included in the literature. And Meta-analysis was performed using RevMan5.3 software.[Results] A total of 1 836 patients were included in 24 RCT articles,and the main indicators and secondary indicators were used for evaluation. The results showed:NMSS scale[MD=-6.19,95% CI=(-7.68,-4.69),Chi2=0.83,DF=3,P<0.000 01,n=302];NMS-Quest scale[MD=-2.17,95% CI=(-2.67,-1.68),P<0.000 01,n=601] UPDRS I scale,no meta-analysis[Chi2=75.91,DF=10,P=0.0002<0.05,n=882],UPDRS Ⅱ Scale[MD=-2.71,95% CI=(-3.34,-2.08),P<0.000 01,n=1 164];PDQ-39 scale[MD=-7.81,95% CI=(-9.97,-5.64)),P<0.000 01,n=407].[Conclusion] From the analysis of current evidences,the combination of Chinese and western medicine in the treatment of non-movement symptoms of Parkinson's disease is effective and superior to the simple basic treatment of western medicine,but due to the limitations of literature quality,further studies are needed to demonstrate. |
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