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| Efficacy evaluation of rt-PA in the treatment of acute ischemic stroke complicated with severe periodontitis |
| Hits 2404 Download times 1692 Received:March 15, 2019 |
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| DOI
10.11656/j.issn.1673-9043.2019.03.13 |
| Key Words
periodontitis;acute ischemic stroke;recombinant tissue plasminogen activator;intravenous thrombolysis |
| Author Name | Affiliation | E-mail | | XIANG Tao | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Peilan | Tianjin Huanhu hospital, Tianjin 300350, China | peilanzhang@sina.com |
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| Abstract
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| [Objective] To investigate the safety and efficacy of intravenous thrombolysis with recombinant tissue plasminogen activator (rt PA) in patients with acute ischemic stroke complicated with severe periodontitis. [Methods] 118 patients with acute ischemic stroke complicated with severe periodontitis were studied retrospectively. Among them, 58 patients received thrombolytic therapy (thrombolytic group) and 60 patients received routine antiplatelet aggregation therapy (control group). The NIHSS scores of patients in each group at admission, 24 hours and 7 days after treatment were analyzed. Modified Rankin score 3 months after treatment, adverse events (symptomatic intracranial hemorrhage, asymptomatic intracranial hemorrhage, gingival hemorrhage, subcutaneous hemorrhage, digestive bleeding, urinary bleeding) and stroke-related deaths within 3 months. The difference of mortality rate and the safety of intravenous thrombolytic therapy in stroke patients with severe periodontitis were analyzed. [Results] Compared with the control group, the levels of NIHSS in the thrombolytic group were significantly lower at 24 and 7 days(P<0.05). The long-term prognosis thrombolysis group was superior to the control group at 3 months(P<0.05), but there was no significant difference in mortality between the two groups. The longterm prognosis of thrombolytic group was better than that of control group at 3 months(P<0.05), but there was no significant difference in mortality between the two groups. The incidence of gingival bleeding in thrombolytic group was significantly higher than that in control group within 3 months of treatment(P<0.05), but there was no significant difference in the incidence of asymptomatic intracranial hemorrhage, subcutaneous hemorrhage and digestive bleeding between the two groups. There were no symptomatic intracranial hemorrhage and urinary bleeding in both groups. [Conclusion] Although rt-PA intravenous thrombolysis in patients with acute ischemic stroke complicated with severe periodontitis increased gingival bleeding, it did not increase the incidence of adverse events such as symptomatic intracranial hemorrhage and patient mortality, and, Intravenous thrombolysis can also significantly improve the prognosis of such patients. |
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